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To the Shareholders of SAGIMET BIOSCIENCES INC SERIES A,

The 2026 Annual Meeting of Shareholders of SAGIMET BIOSCIENCES INC SERIES A will be held on June 12, 2026 for Shareholders of record as of April 17, 2026.

Your vote is important, so please vote at your earliest convenience.

If you are a registered holder, to vote your proxy you will need your account's unique 11-digit Control Number, which is located in your proxy e-mail or located beneath the company and account number on the upper-right side of your proxy material.

To vote online, please click Vote Your Online Proxy.

To vote by telephone, call toll - free 1 - 800 - PROXIES (1 - 800 - 776 - 9437) in the United States or 1 - 201 - 299 - 4446 from foreign countries and follow the instructions.

If you own shares through a broker, please follow the instructions that were provided to you by your broker/financial institution.

If you have any questions, please contact AST.

Thank You,

Equiniti Trust Company, LLC

Transfer Agent for SAGIMET BIOSCIENCES INC SERIES A