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CALITHERA BIOSCIENCES INC

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To the Shareholders of CALITHERA BIOSCIENCES INC,

The 2021 Annual Meeting of Shareholders of CALITHERA BIOSCIENCES INC will be held on June 11, 2021 for Shareholders of record as of April 12, 2021.

Your vote is important, so please vote at your earliest convenience.

To Request Paper Copies of Materials

If you are a shareholder of record who received a Notice of Availability of Proxy Materials, and wish to elect to receive a paper copy of the proxy materials, please visit the following site: Request CALITHERA BIOSCIENCES INC Proxy Materials.

Alternatively, you may request a hardcopy of the proxy materials via e-mail at info@astfinancial.com or phone at 1-888-Proxy-NA (1-888-776-9962) or 1-718-921-8562. Be sure to include your control number in the e-mail.

If you own shares through a broker, please follow the instructions that were provided to you by your broker/financial institution.

If you have any questions, please contact AST.

Thank You,

American Stock Transfer & Trust Company, LLC

Transfer Agent for CALITHERA BIOSCIENCES INC